From 1935, a Wehrmacht reserve hospital with a three-storey main building and several pavilions with 1,800 beds was built on a trapezoidal site between today's Konrad-Adenauer-Ring, Holsteinstrasse and Teutonenstrasse. On June 7, 1945, it was confiscated by the Americans, who over the years expanded what was now the US Military and US Air Force Hospital into the largest American military hospital outside the USA. When the US armed forces began to reduce their troop strength in Europe, this use came to an end in 1995.

In February 1996, a concept for a new police headquarters was presented. In April 1996, the Americans officially handed over the property to the Federal Republic of Germany, which sold it to the state of Hesse in December 1997 for around DM 35 million. The first planning contracts for conversion work were awarded in 1997. In addition to the police headquarters, the Wiesbaden public prosecutor's office, the probation service, the state office for the protection of the constitution, the state audit office, the land registry office and the veterinary office were also to be housed on the site. Of the 16 buildings available, eight were earmarked for the police. For all conversion measures, it had to be taken into account that the entire ensemble was a cultural monument in accordance with the Hessian Monument Protection Act. Construction work began in 2001. The operations center and central police custody were housed in a modern new building. The police headquarters moved into the building in October 2004.